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To study single molecules, Block has pioneered the use of optical tweezers, tiny laser-based "tractor beams" that produce miniscule piconewton forces to drag around molecules and allow measurements of displacements on the order of a nanometer. "You can stop and stall molecules, w follow their motion. Recently, we've studied the backtracking of RNA polymerase: when it makes a mistake, it can actually back up by five bases, scoop off the wrong thing and start again," says Block. While biological nanotechnology "hasn't even arrived at its infancy yet," says Block, "biological nanoscience is a very exciting place to be right now, because the techniques now exist to truly study proteins, and we're learning so much about them."

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All over campus, Stanford has eagerly embraced the "grand challenges" of nanotechnology. Just this April, the Stanford Nanofabrication Facility (SNF) hosted an open house to celebrate its selection to be part of the National Science Foundation-sponsored National Nanotechnology Infrastructure Network sprawling across thirteen universities nationwide. Along with the new Nanocharacterization Laboratory expanding the SNF, the nearly finished Manoharan lab that Stanford students bike past on the way to physics lab embodies the prominent place nanotechnology has in Stanford research for years to come. Specifically, the Manoharan lab is equipped to manipulate matter on an atomic level. Here's a cross-section of nanotechnology research currently being pursued at Stanford:
Yet, there remains a problem with the "nano" in both nanoscience and nanotechnology. "Nanotechnology's a term with not too much new in it. It existed a long time ago," says Dai. Indeed, the characteristic length of bonds that have always been under scrutiny in the molecular sciences is on the order of a nanometer. Chidsey adds, "I worry that the term confuses people about what's important: the length scale itself is not important." Rather, it is the novel properties that structures exhibit at the nanoscale that is. As Dai puts it, "We work on carbon nanotubes not because they are small, but because they are interesting. They just happen to be nano." For all the problems with the term nanotechnology, though, it may have done some good. Chidsey remarks, "Just as nanotechnology has attracted the attention of outsiders, it also stimulates us internally: it provides a context for tackling and defining grand challenges-things so out there you wouldn't tackle them otherwise."